At the age of 53 Cary Grant participated in a series of experiments with LSD. In his autobiography he records his perceptions, and they read like the teachings of the Buddha.
...by 1956, lacking the foundation of early spiritual training and suspecting that there was more happiness available than I seemed able to grasp, I had grown much more tolerant of, and receptive to, the knowledge of others. Other searchers, other sharers. Humanitarians in all fields of endeavor. At the age of 53, after three unsuccessful marriages, either something was wrong with me or, obviously, with the whole sociological and moralistic concepts of our civilization.
I learned may things in the quiet of that small room. I learned to accept the responsibility for my own actions, and to blame myself and no one else for circumstances of my own creating. I learned that no one else was keeping me unhappy but me; that I could whip myself better than any other guy in the joint.
I learned that all clichés prove true; which is, of course, the reason for their repetition, even when the meaning has been forgotten by the constant usage.
I learned that everything is, or becomes, its own opposite. A theory I can sometimes apply, but would find difficult to convey.